Dermal absorption and toxicity assessment

The relationship between structure and barrier function of skin dermal metabolism systemic toxicity in man secondary to percutaneous absorption. Part 1 Modelling of dermal risk assessment: occupational skin disease - a case study current issues inthe in vitro measurement of percutaneous absorption investigation of the skin permeation in vitro prediction -physiological models prediction - simple risk models and overview of dermal risk assessment cutaneous microdialysis for human in vivo dermalabsorption studies physicochemical determinants of stratum corneum permeation. Part 2 Pharmeceuticals: in vitro/in vivo correlations in transdermal drug delivery irritancy of topical chemicals and transdermal delivery systems chemical penetrationenhancement - possibilities and problems drugs used for skin diseases drugs for pain and inflammation site of effects iontophoresis topical therapeutic agents used in wound care. Part 3 Cosmetics: regulation of cosmetics in the United States experimental design considerations and use of in vitro skin penetration data in cosmetic risk assessment percutaneous absorption of hair dyes sunscreens - toxicological aspects exposure to fragrances - their absorption and potential toxicity. Part 4Environmental: dermal absorption and toxicity assessment human skin penetration by metal compounds soil contamination -theoretical descriptions percutaneous absorption of hazardous substances from soil and water bathing water - percutaneous absorptionof water contaminants ultrastructural effects of some solvents and vehicles on the stratum corneum and other skin components - evidence for an extended mosaic-partitioning model of the skin barrier.