Optical Coherence Tomography normative peripapillary retinal nerve fiber layer and macular data in children ages 0-5 years

Purpose To determine reference values for the peripapillary retinal nerve fiber layer (pRNFL) and macula in children 0–5 years of age. Design Prospective cross-sectional study. Methods This study was set in a single large academic pediatric ophthalmology practice. Healthy, full-term children 0 to Results Data were obtained from normal eyes of 57 participants (mean age 2.28 ± 1.50 years). Mean global pRNFL thickness was 107.6 ± 10.3 μm. Mean global pRNFL thickness was not dependent on age but showed a negative relationship with axial length (P = .01). The mean total macular volume was 8.56 ± 0.259 mm3 (n = 38). No relationship was found between total macular volume and age. Ganglion cell layer, ganglion cell complex, and inner nuclear layer volumes showed an inverse relationship with age while the photoreceptor layers showed a logarithmic increase with age. Conclusions Global pRNFL thickness measurements remain stable over time. Macular volume and thickness values of segmented retinal layers reflect the development of the macula with age.