N-Cadherin-Mediated Activation of PI3K/Akt-GSK-3β Signaling Attenuates Nucleus Pulposus Cell Apoptosis Under High-Magnitude Compression

Pei Li,Zherui Liang,Gang Hou,Lei Song,Ruijie Zhang,Yibo Gan,Chengmin Zhang,Yichun Xu,Qiang Zhou

N-Cadherin-Mediated Activation of PI3K/Akt-GSK-3β Signaling Attenuates Nucleus Pulposus Cell Apoptosis Under High-Magnitude Compression

2017

Pei Li
Zherui Liang
Gang Hou
Lei Song
Ruijie Zhang
Yibo Gan
Chengmin Zhang
Yichun Xu
Qiang Zhou

Background/Aims: Mechanical overloading-induced nucleus pulposus (NP) apoptosis plays an important role in the pathogenesis of intervertebral disc degeneration. N

Keywords:

PI3K/AKT/mTOR pathway
Protein kinase B
Biochemistry
Intervertebral disc
Cancer research
Cadherin
Apoptosis
Nucleus
Biology
Cell biology
Pathogenesis
Flow cytometry
LY294002
Blot

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