PP-048 Prediction value of MELD scoring system on prognosis in patients with acute-on-chronic hepatitis B liver failure after plasma exchange and lamivudine treatment

that of cirrhosis group (P 0.001); additionally, there was statistically significant difference between CLF and ACLF patients (P< 0.001). Plasma Af-Gc globulin significantly positive correlated with ALB, ALT, AST, CHE (P was 0.001, 0.001, 0.001, <0.001 respectively), while weak positive correlated with TBIL, PLT. Meanwhile, there was significantly negative correlation between plasma Af-Gc globulin and Child Pugh score (P= 0.02), while weak negative correlated with INR. The level of Af-Gc globulin in liver failure patients who were infected by ascites or hydrothorax were markedly lower than that of non-infected (P= 0.015), the levels of Af-Gc in encephalopathy presence were lower than encephalopathy absent (P= 0.083). No statistically significant difference was noted in non-survivors and survivors of liver failure patients. Conclusions: Plasma Af-Gc globulin levels in liver failure patients were significantly reduced compared with cirrhosis and healthy controls, but it can not be used to evaluate the prognosis of liver failure patients. Abbreviations: Alanine aminotransferase (ALT), aspartate aminotransferase (AST), choline esterase (CHE), Albumin (ALB), total bilirubin (TBIL), palsma international normalized ratio of prothrombin time (INR), platelet (PLT)