Clinical Symptoms of Skin, Nails, and Joints Manifest Independently in Patients with Concomitant Psoriasis and Psoriatic Arthritis

Abstract This study correlated assessment tools for evaluating the severity of skin, nail, and joint symptoms in patients with psoriasis(Pso) and psoriatic arthritis (PsA). Adults with plaque Pso (with or without PsA) were enrolled from four U.S. institutions.Patients were evaluated using a novel 10-area Linear Psoriasis Area and Severity Index (XL-PASI), Psoriatic ArthritisAssessment (PsAA), Psoriatic Arthritis Screening and Evaluation Questionnaire (PASE), Nail Assessment (NA) and JointAssessment (JA) tools, Psoriasis Weighted Extent and Severity Index (PWESI), and Lattice Physician Global Assessment (LS-PGA). Correlations between assessment tools and individual items in the assessment tools were performed. Data from 180patients (55 with PsA) were analyzed. Highest correlations between tools (r=0.77–0.88) were between the XL-PASI, PWESIand LS-PGA. Individual items in the XL-PASI correlated with items in the PWESI for extent skin symptoms, but not for allbody areas. Overall, correlations were seen between hands and feet, between face and scalp, and between buttocks, chest,and back. Only low correlation was seen between items assessing joint symptoms with items assessing skin symptoms.These data support the notion that the complex phenotype of psoriatic disease requires instruments that assess the severityof skin, nails, and joints separately.