Nickel-catalyzed cross-coupling of organoaluminum reagents with alkynylhalides for the synthesis of symmetrical and unsymmetrical conjugated 1,3-diynes derivatives
2020
Abstract We describe a convenient method for the synthesis of symmetrical and unsymmetrical conjugated 1,3-diynes from cross-coupling reactions of organoaluminum with alkynylhalides: The cross-coupling reaction of organoaluminum (0.75 mmol) with alkynylhalides (0.5 mmol) mediated by Ni(acac)2 (5 mol%)/DPPE(10 mol%) at room temperature in DME may produce symmetrical and unsymmetrical conjugated 1,3-diynes in moderate to good yields(up to 98%) derivatives. Their structures have been determined by HRMS and 1H(13C)NMR data. On the basis of the experimental results, a possible catalytic cycle has been proposed.
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