Transdermal Electroneurostimulation as the Promising Method for Hyperglycemia Treatment

Transdermal electroneurostimulation (TENS) with sequential packs of two-phase electric pulses with special frequency shows potential effectiveness in hyperglycemia treatment. Alloxan-induced diabetic rats (170 mg/kg b.w.) were treated with TENS for 14 day, 20 minutes a day. Such impact significantly decreases fasting blood glucose level from $10.4 \pm 0.4$ mmol/l (sham-group) to $7.0 \pm 0.24$ mmol/l (TENS-group) and glycated hemoglobin level from $5.6 \pm 0.3$% to $4.2 \pm 0.3$% respectively. The blood glycemia improvement remains at least 1 week after the treatment. However, such treatment has no effect on the blood serum AST, ALT and urea level. Hematological analysis shows middle cells stimulation after TENS-treatment. There are no significant changes in pancreas islet number or its areas and islet cell number. Nevertheless, morphological analysis indicates local pancreas hemodynamics improvement. Our study suggests that TENS-therapy could bring some benefits as an additional noninvasive method of hyperglycemia control and it requires further examinations of possible effects on animal physiology.