Microvascular and Systemic Impact of Resuscitation with Pegylated Carboxyhemoglobin-Based Oxygen Carrier or Hetastarch In A Rat Model of transient hemorrhagic Shock

ABSTRACTBACKGROUND:Hemorrhage is the leading cause of preventable, traumatic death. Currently, pre-hospital resuscitation fluids provide preload but not oxygen carrying capacity—a critical blood function that mitigates microvascular ischemia and tissue hypoxia during hemorrhagic shock. Solutions con