Anti-HIV activity of quassinoids

Abstract Eighteen quassinoid glycosides and nine known quassinoids were tested for inhibitory activity against HIV replication in H9 lymphocytic cells. Of the compounds tested, shinjulactone C ( 20 ) demonstrated the highest anti-HIV activity (EC 50 = 10.6 μM) in the absence of cytotoxicity with a therapeutic index of >25.