Diagnosis of Primary CNS Lymphoma

In difficult-to-diagnose cerebral disease, brain biopsy is often necessary for optimal treatment. Primary central nervous system lymphoma (PCNSL) can mimic diverse neurological diseases and can remit through administration of corticosteroid alone. Corticosteroid use should be discontinued in the pre-biopsy period to improve diagnostic accuracy in suspected cases of PCNSL. We report on a 52 year-old female who presented with a recent history of introverted social behavior despite a history of normal social interactions. After a series of diagnostic evaluations, we determined that she suffered from primary CNS lymphoma.