Immune Related Cutaneous Adverse Events Due to Checkpoint Inhibitors.

Abstract Objective This article will familiarize the reader with the most common cutaneous adverse events with immune checkpoint inhibitors, as well as their grading and treatment. Data Sources Recent research articles, relevant review articles, and case series/reports in English from PubMed database mostly from 2010 onwards. Study Selections Most data are from retrospective studies and case series. Older studies regarding mechanism were included if they were of particular importance. Results : An understanding of this review should enable the reader to identify specific skin disorders in patients receiving immune checkpoint inhibitors (CPI), grade the adverse event, and be able to treat or refer the patient as needed. Conclusion Allergists/immunologists need to be familiar with these immune-related adverse cutaneous adverse events as their incidence will increase with the everexpanding use of CPI and in particular as patients will certainly continue to be referred suspecting drug allergies.