Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of arg-gly-asp (RGD)
1996
Abstract Partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects of experimental lung metastasis of murine melanoma and adenosine 5′-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient theraputic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation.
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