Tetrahydroisoquinoline as a phenylalanine replacement in renin inhibitors
1994
Abstract A series of compounds incorporating the tetrahydroisoquinoline (THIQ) fragment was synthesized and evaluated for renin inhibition. Stereochemistry around the alpha carbon, as well as nitrogen substitution was investigated. Selected compounds were tested for in vivo activity in a conscious high renin cynomolgus monkey model.
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KQI