ORGANIC CHEMISTRY | RESEARCH ARTICLE Synthesis and some novel transformations of a spiro 4-thiazolinone derivative and its antimicrobial activities

2 * Abstract: Present communication deals with the synthesis and characterization of various spiro thiazolinone heterocyclic compounds. 4-(4-(6,7-dihydrothieno(3,2-c)pyri- din-5(4H)-ylsulfonyl)phenyl)-1-thia-4-azaspiro(4.5)decan-3-one (5) was synthesized by facile and fast heterocyclization reaction, which further underwent condensation with 4-chlorobenzaldehyde to afford 2-(4-chlorobenzylidene)-4-(4-(6,7-dihydrothieno(3,2-c) pyridine-5(4H)-ylsulfonyl)phenyl)-1-thia-4-azaspiro(4.5)decan-3-one (6). Resultant com- pound was used as precursor for the preparation of some bioactive fused heterocyclic compounds (7-10). All the synthesized compounds were duly characterized by elemen- tal analyses and various spectroscopic techniques. All the synthesized compounds were screened for their antimicrobial activity and it was observed that as the fusion of heterocyclic rings increases its shown higher antimicrobial activities.