An in vivo biocompatible study of antimicrobial biocomposite membrane: preliminary outcome

Guided Bone Regeneration (GBR) is a surgical procedure that uses barrier membranes to treat bony defects. The membrane plays an important role in proper bone regeneration. A triple-layered membrane containing poly (lactic-co-glycolic acid) (PLGA) matrix with bioactive apatite filling and lauric acid (LA), which is a naturally derived antimicrobial substance is one of the examples of membrane used. Critical Size Defect (CSD) is an experimental method in evaluating the effectiveness of newly developed biomaterials to stimulate bone formation before clinical application. New Zealand White Rabbits (Oryctolagus cuniculus) are commonly used rabbits for laboratory research and industry toxicology studies. By using the CSD technique in the New Zealand White Rabbit, this study seeks to investigate the biocompatibility and new bone growth potential of the bio composite membrane through in vivo analysis.