Effect of low molecular weight heparin in the treatment of hypercoagulable state of ulcerative colitis

Objective To study the effect of low molecular weight heparin in the treatment of hypercoagulable state of ulcerative colitis. Methods 116 patients with ulcerative colitis hypercoagulable were enrolled in the study. Thepatients were divided into two groups according to the random number table, 58 cases in each group.The conventional group was treated with conventional therapy, and the low molecular weight heparin group was treated with low molecular weight heparin on the basis of conventional therapy. Both two groups were treated for 15 days. The degree of hypercoagulability, the inflammatory status of the patients before and after treatment, and the platelet count and plasma D-dimer levels before and after treatment were compared. Results The improvement rate of hypercoagulable state of the low molecular weight heparin group was 96.55%, which was higher than 87.50% in the routine group(χ2= 4.921, P<0.05). There were no statistically significant differences in platelet count and plasma D-dimer level between the two groups before treatment(all P<0.05). The platelet count and plasma D-dimer level were significantly lower in the low molecular weight heparin group(t=7.255, 8.013, all P<0.05). The levels of TNF-α and CRP in the low molecular weight heparin group were significantly lower than those in the control group(t=9.245, 8.256, all P<0.05). Conclusion The effect of low molecular weight heparin in the treatment of hypercoagulable state of ulcerative colitis is effective, which can effectively reduce the inflammation level and hypercoagulable state of the patients, it is beneficial and feasible for the prognosis of the patients. Key words: Colitis, ulcerative; Low molecular weight heparin; Chemokines