Abstract 17882: GlycA, a Novel Inflammatory Marker, Is Strongly Associated With Mortality in Both Women and Men

Introduction: GlycA is a novel inflammatory marker highly associated with cardiovascular (CV) morbidity and mortality. Hs-CRP is known to have a strong association with mortality in men, but not women; whether the association between GlycA with mortality differs by sex is not known. Methods: GlycA was measured using NMR spectroscopy in the CATHGEN biorepository linked to mortality data (n=8,436). The proportional hazards assumption was violated in cox hazards modeling; thus flexible parametric modeling was used. Interaction between sex and GlycA in full model adjusted for age, race, history of DM, HTN, obesity, smoking, and prior MI was significant (p Results: Over a mean of 6.6 years, 28.2% women and 30.9% men died. Women had greater median GlycA plasma concentrations at baseline (387.4 vs. 357.3 μmol/L; women vs. men). Compared to the lowest quartile of GlycA, those in the highest quartile of GlycA had a strong association with mortality in both sexes; hazard ratio 2.24 (p Conclusions: GlycA has a strong, graded association with mortality by increasing quartile of GlycA in both men and women; this is in contrast to hs-CRP. More research is needed as to whether GlycA may be a more reliable measure of inflammation in women.