Prevalence of Herpes -, Measles morbillivirus-, Parvovirus B19 - and Rubella viruses Immunoglobulin G among women with chronic Hepatitis B of reproductive age in Denmark: A cross-sectional study.

Abstract Objectives The aim of this study was to investigate whether the seroprevalence of IgG antibodies against seven viruses (cytomegalovirus, herpes simplex virus 1&2, measles morbillivirus, parvovirus B19, rubella and varicella-zoster virus), which can potentially compromise maternal and fetal wellbeing, differs based on country of origin among women with chronic Hepatitis B (CHB). Method This study was a single-center, hospital based cross-sectional study. The study included women with CHB 15-45 years of age, included in the Danish Database for Hepatitis B and C. Seroprevalence estimates were calculated with a 95% confidence interval and were compared between age groups, regions of origin and to the general population. Results 177 women were included in the study. Overall, the seroprevalences of antibodies were similar among women with CHB with origin outside Denmark and compared to the general population in Denmark, but there was a notable difference in the seroprevalence of antibodies against herpes simplex 2 between women from Africa (37.1% CI 95% 22.0;55.1) and women from the Middle East (2.5% CI 95% 0.1;14.7). Conclusion Women with CHB with origin outside Denmark do not appear to differ based on origin or be at greater risk of acquiring these viruses during pregnancy compared to the Danish population.