Preparation of drug containing extrusion pellets with a thermoplastic base. 2. The optimization of drug release

: The drug release can be improved by incorporation of additional auxiliary substances in extrusion pellets. The experimental results proved evidence, that especially the incorporation of calcium carbonate or polyvinylalcohol leads to an increase of the drug release. Their content must amount to 40%. In preparing thermically unstable drugs in pellets, it is necessary to prepare these products under thermically mild conditions. By using ethylene-vinyl-acetate-copolymers these unstable drugs can be incorporated in extrusion pellets.