OC-024 Detect inspect characterise resect and discard 2: are we ready to dispense with histology?

Introduction Colorectal cancer is preventable through polypectomy at colonoscopy. Most polyps are adenomas, with malignant potential, or hyperplastic with no malignant risk. Most adenomas are small ( Method The accuracy of surveillance interval assigned by NBI optical diagnosis was compared with the current reference standard of histopathological diagnosis in a prospective, blinded calibration study in 6 community hospitals in northeast England. Adults undergoing routine colonoscopy between July 2012 and February 2014 were eligible. Exclusion criteria were: inflammatory bowel disease; polyposis syndromes; pregnancy. Participating colonoscopists (n = 28) passed a validated training module utilising the NBI International Colorectal Endoscopic (NICE) classification. Optical diagnosis was provided for all polyps Results Of 1688 patients recruited, 723 (42.8%) had polyps Conclusion The findings of this study suggest that NBI optical diagnosis cannot yet be recommended for use in routine clinical practice. Sensitivity per polyp was acceptable when ≥2 NICE features were present. Further work is required to determine if variation is due to colonoscopist or polyp characteristics. Disclosure of interest None Declared.