Importance of CCL25 in the attraction of T cells and the role of IL-7 on the signaling pathways in intestinal epithelial cells

Abstract We have demonstrated an inflammatory process triggered by a dietary antigen accompanied with an increase of TNF-α in an experimental model of secondary immunodeficiency. TNF-α regulates the increase of γδ T subpopulation both in lamina propria and in the intestinal intraepithelium, where IL-7 influences γδ T cells development. TECK (CCL25) is important in the attraction and generation of T and B lymphocytes to the small intestine, lamina propria and intraepithelium. In the present study we evaluate CCL25 and IL-7 mRNA levels, by semiquantitative RT-PCR in intestinal epithelial cells. Lower levels of CCL25 mRNA were detected in animals after re-feeding compared to the well-nourished ones ( P P All the above findings may lead us to conclude that we are in the presence of a mechanism by which γδ+T cells are increased in the intestinal villi, through different signaling pathways mediated by CCl25 and IL-7.