Uveitis reactivation following recombinant zoster vaccination

Abstract Purpose Describe three cases of uveitis reactivation following immunization with recombinant zoster vaccine (RZV). Observations One patient developed reactivation of previously controlled multifocal choroiditis within one week of receiving RZV, requiring treatment with systemic corticosteroids. Two patients with previously controlled anterior uveitis developed new anterior segment inflammation after RZV; both were treated with topical corticosteroids and systemic antiviral therapy. Conclusion and importance Uveitis recurrence is an infrequent but serious potential ocular side effect of recombinant zoster vaccination.