Does isolation site of Enterobacteriaceae affect susceptibility against Imipenem

Objective: To determine the susceptibility pattern of Enterobacteriaceae isolated from different body sites against Imipenem Methodology: We conducted a retrospective analysis of the susceptibility pattern of Enterobacteracaea against Imipenem, isolated from clinical specimens between April 2014 to July 2017 at Rawal General and Dental hospital, Islamabad, Pakistan. Results: A total of 575 Enterobacteriaceae were isolated from urine, pus and other specimens. These specimens were taken from 163 males and 412 females. The ages of patients ranged from 1 to 80 years. Escherichia coli was among the most common isolate from all the specimens (n=359), followed by Klebsiella pneumoniae (n=92) and Enterobacter cloacae (n=51). Among the total isolates (n=575), 90.78% (n=522) were susceptible to Imipenem. Isolates from urine revealed 95.52% susceptibility against Imipenem which was significantly higher than the pus (74.22%) and other specimens isolates (83.01%) susceptibility against Imipenem(p