Gender modulates development of the metabolic syndrome phenotype in fructose-fed rats
2013
We analyzed the effects of a fructose-rich diet (FRD) to test the assumption
that the expression of metabolic syndrome phenotype is different in male and
female rats. Two-way ANOVA revealed a significant effect of FRD on feeding
behavior and carbohydrate/lipid metabolism. The increased caloric intake in
FRD rats of both sexes was followed by a cluster of gender-specific changes
typical for the metabolic syndrome. Female rats were characterized by
decreased glycemia, increased triglycerides, enlarged visceral adipose tissue
and increased absolute mass of liver, without changes in systolic blood
pressure and insulin sensitivity. In contrast, male rats developed less
disturbances in physical and biochemical characteristics, but blood pressure
and insulin sensitivity were impaired by FRD. The results emphasize the
detrimental effects of fructose consumption on cardiovascular risk and
insulin action in males, whereas females are affected by other metabolic
disturbances. These results support the idea of gender-dependent differences
in the expression of the metabolic syndrome phenotype. [Projekat Ministarstva
nauke Republike Srbije, br. 41009]
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