PO-1003 Characteristics Of The Immune Response To Influenza Vaccine In Children With Allergic Diseases

Background Patients with chronic diseases, including atopic bronchial asthma (BA), should be vaccinated annually against influenza. Purpose. To determine the impact of vaccination against influenza in the state of immune response in children with atopic BA. Object Studied immune status of 39 children with moderate persistent BA in children from 7 to 14 years, which annually for three years were vaccinated influenza subunit vaccine. Methods Compared the levels of serum markers of activation of apoptosis and immune cells before and one month after vaccination. Results. After the vaccination was determined by the tendency to increase of level of IFNγ and IL12 in the serum. Also demonstrated increased in 1.3 times sCD25 (p < 0.05), in 1.6 times IL8 (p < 0.001), reduction in 1.5 times IL4 (p < 0.001), in 1,3 times TNFα (p < 0.05). In vaccinated children was revealed a tendency to increase sCD25 and the reduction of sCD30, sCD95 (p < 0.05), with the all of the listed indicators were significantly rejected from the reference levels. Reliable dynamics of the content of eotaxin, soluble ligands markers of apoptosis sFASL, TRAIL (Apo-2L), the enzyme Caspase-1/ICE and protein Annexin V have been identified. Conclusions The data show a pronounced inflammatory process in children with atopic bronchial asthma. At the same time, the observed dynamics of the studied indicators can be interpreted as evidence of an absence of negative impact of vaccination on the various links of the immune response in children with atopic bronchial asthma, including on the processes of activation and apoptosis.