Antihypertensive therapy and incident gout

Evaluation of: Choi HK, Soriano LC, Zhang Y, Rodriguez LA. Antihypertensive drugs and risk of incident gout among patients with hypertension: population based case–control study. BMJ 344, d8190 (2012). A nested case–control study aimed at determining the independent associations of antihypertensive drugs with the risk of incident gout among individuals with hypertension. Calcium channel blockers and losartan were associated with lower risk of incident gout among individuals with hypertension. By contrast, diuretics, β-blockers, angiotensin-converting enzyme inhibitors and nonlosartan angiotensin II receptor blockers were associated with an increased risk of gout. In addition, both duration of treatment and dose influenced the magnitude of the response to both calcium channel blockers and losartan.