Disruption of Hepatic Leptin Signaling Protects Mice from Age- and Diet- Related Glucose Intolerance Running Title: Liver Leptin Signaling and Glucose Tolerance

1 Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada 2 Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom 3 Departments of Medicine and Neuroscience, Albert Einstein College of Medicine, New York, New York, U.S.A 4 Current Affiliation: Department of Biochemistry and Molecular Biology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada 5 Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.