Resveratrol inhibits tumor progression by down-regulation of NLRP3 in renal cell carcinoma.

Abstract Renal cell carcinoma (RCC) is one of the most common urologic malignant tumors. Current chemotherapy is not effective to RCC and results in some side-effects. Resveratrol (RSV) has been reported to exert anti-tumor effects in some cancer cells; however the mechanism is not fully understood. Herein, we aimed to determine the anti-cancer effect of RSV on RCC, and further explore the underlying molecular mechanism in this process. We found that RSV inhibited tumor cells proliferation, migration, invasion, and increased apoptosis of RCC either in vivo or in vitro. RSV significantly down-regulated expressions of NLRP3 and its down-stream genes. Inhibition of NLRP3 by NLRP3 small interfering RNA (siRNA) mimicked the effects of RSV on RCC cells. These results suggested that RSV could exert anti-tumor effect by depressing activity of NLRP3, and NLRP3 would be a promising clinical therapeutic strategy for RCC.