PROBLEMS OF ADEQUATE ACCESS TO A MOUTH OF LABORATORY ANIMALS FOR ORAL CAVITY PATHOLOGY MODELING

The most important link in structure of med-ico-biological experiment is laboratory animals. Requirements of scientists to quality of laboratory animals, to their standardization on a genotype, maintenance and feeding conditions, testability on micro-fl ora and parasitic organisms now have es-sentially increased. Laboratory animals are subject to various diseases. For example, very common situations are exogenous parasitoses, such as tri-chodectoses and sarcoptoses. Frequently sarcop-toses and trichodectoses meet in association. De-spite the many new pharmaceuticals for treatment of this exoparasitoses in the Russian veterinary market, there are no accurate schemes of treat-ment and dosages for rodents. Summarising the above-stated and considering a wide circulation of sarcoptoses and trichodectoses, it was found expedient to investigate a spectrum of insecticid and acaricid activity of preparations accessible in veterinary drugstores of Volgograd (Russia). It is revealed, that the most presented preparations are «NeoStomosan», «Celandin Sprey», «Leopard», «Frontline Sprey» and «Zoopowder Puldis». Three from these («Leopard», «NeoStomosan», «Zoo-powder Puldis») have been chosen for estimation of acaricid and insecticid effects. All preparations are recommended for struggle with parasitic inva-sions of cats and dogs whereas an exact dosage for small rodents is not revealed. The experiments were carried out on 120 out-breed sexually mature male rats (190-210 g), ac-cording to the international norms and rules of work with vertebrate animals (Strasbourg, 1999). It was confi rmed clinically and morphologically that all animals were parasitized with the following: sarcoptos bodies, ears, superciliary arches and ex-pressed diffuse trichodectoses. Animals have been divided into 4 equivalent groups. Animals of the fi rst group were exposed by the «Leopard» spray, the second group – by «Leopard» drops, the third group was processed by «Puldis», and the fourth group – by «NeoStomosan». The degree of parasit-ic invasion was estimated every day on an original scale by «Estimations of an external condition of laboratory animals» within 6 days.Our results indicate that the activity degree of the investigated preparations can be distributed as: «Leopard»> «Puldis»> «NeoStomosan», and by effi ciency (the speed of full clearing from parasi-tes) – as: «Puldis»> «Leopard»> «NeoStomosan».The work is submitted to the International Sci-entifi c Conference «Fundamental Research», Do-minican republic, 13-24 April 2011, сame to the editorial offi ce on 10.02.2011