Huntingtin Yeast Two-Hybrid Protein K (HYPK): An Intrinsically Unstructured Heat Shock Inducible Protein with Diverse Cellular and Molecular Functions

Introduction Huntingtin Yeast Two-Hybrid Protein K (HYPK) was identified as huntingtin interacting protein in yeast 2 hybrid (Y2H) assay in 1998. Since then, HYPK has been characterized and shown to participate in diverse cellular functions. HYPK is shown to possess chaperone like activity in vitro and in vivo and regulated by Heat Shock Factor 1 (HSF1) by binding to the promoter of HYPK in response to heat shock (HS). The goal of the present review is to describe and evaluate current information of HYPK.