Clinical Evaluation of the Dentifrice Containing Tranexamic Acid and Dipotassium Glycyrrhizinate for Periodontal Disease

The purpose of this study was to investigate the clinical effect of dentifrice R containing 0.05% tranexamic acid and 0.05% dipotassium glycyrrhizinate on the improvement of periodontal disease compared with dentifrice T containing 0.05% tranexamic acid.Subjects were 148 adults who had no serious oral or systemic diseases. They were divided into two groups equally and performed toothbrushing twice a day for four weeks with dentifrice R or T.The PMA index, redness, swelling, and plaque score were selected as indices for clinical evaluation of periodontal condition.The results obtained were as follows.1) Dentifrice R was significantly superior to dentifrice T in the improvement of PMA index (p<0.01), redness (p<0.01) and swelling (p<0.05). There was no significant difference in the improvement of plaque score between dentifrices R and T.2) The mean improvement rates of dentifrice R and dentifrice T were 37.0% and 26.3% in PMA index, 40.7% and 25.2% in redness, and 36.7% and 29.9% in swelling, respectively.3) No particular side effects were observed during this clinical study.