The Synthesis of Cationic Glycerolipid Acetals Containing Aliphatic and Heterocyclic Bases

1,3-Dioxolane series cationic lipids containing residues of aliphatic or heterocyclic nitrogenous bases were synthesized. The bases were attached to the glycerol backbone either directly (piperazine) or via a spacer group through a thioether bond.