Pinin facilitated proliferation and metastasis of colorectal cancer through activating EGFR/ERK signaling pathway

// Zhigang Wei 1, * , Wenhui Ma 1, * , Xiaolong Qi 1, * , Xianjun Zhu 1 , Yutian Wang 2 , Zhuoluo Xu 1 , Jun Luo 1 , Da Wang 1 , Weihong Guo 1 , Xiaomei Li 2 , Sainan Xin 2 , Jiang Yu 1, 2 , Guoxin Li 1 1 Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China 2 Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China * These authors have contributed equally to this work Correspondence to: Guoxin Li, email: gzliguoxin@163.com Jiang Yu, email: balbc@163.com Keywords: colorectal cancer, PNN, EGFR/ERK, metastasis Received: January 16, 2016     Accepted: March 28, 2016     Published: April 15, 2016 ABSTRACT Increasing emphasis has been put on the influence of desmosome related proteins on progress of colorectal cancer (CRC). Pinin (PNN) is a desmosome-associated molecule that has been reported its overexpression could increase desmoglein 2 (DSG2) and E-cadherin (E-ca) levels. However, it was documented that DSG2 and E-ca had opposite functions in CRC. Thus, we attempted to elucidate function and mechanism of PNN in CRC. Herein, we revealed that overexpression of PNN was significantly correlated with the aggressive characteristics and indicated poor overall survival of CRC patients. In addition, the proliferation, invasion in vitro , and tumorigenic growth, metastasis in vivo were also promoted by the up-regulation of PNN. It was also verified that up-regulation of PNN increased the expression of DSG2 and activated the EGFR/ERK signaling pathway. Our findings suggested that PNN, as a valuable marker of prognosis, has important influence on the progression of CRC.