A New Method to Modify the C-4 Position of 10-Deacetylbaccatin III
2010
We have developed a new method to modify the C-4 position of 10-deacetylbaccatin III (5) using the C-4 acetoxy anion of the 13-keto derivative (7) and various alkyl halides. The method developed herein shound be very useful for the preparation of C-4 modified taxoid analogs.
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