Synthesis, characterization, and urease inhibitory activity of two copper(II) complexes of cyclohexanecarboxylate

The crystal structures of two copper(II) complexes of the cyclohexanecarboxylate ligand, namely [Cu(C6H11CO2)2(H2O)2]·H2O (1) and [Cu(dpyam)2(C6H11CO2)](NO3)·H2O (2) (C6H11CO2H = cyclohexanecarboxylic acid; dpyam = di-2-pyridylamine), have been determined by single-crystal X-ray analysis. Complex 1 contains the square-planar trans-CuO4 chromophore, while 2 shows the square pyramidal cis-distorted octahedral CuN4OO′ chromophore. Both complexes were found to show strong inhibitory activity against jack bean urease (IC50 = 1.75 and 8.57 μM for 1 and 2, respectively), when compared with acetohydroxamic acid (IC50 = 63.12 μM).