Emerging Cell-Based Therapies in Chronic Lung Diseases: What About Asthma?

Asthma is a widespread disease characterized by chronic airway inflammation which causes substantial disability, impaired quality of life, and avoidable deaths around the world. The main treatment performed in asthmatic patients is based on the administration of corticosteroids which although improving the quality of life, prolonged use can interfere with extracellular matrix elements. Therefore, cell-based therapies have been emerging as a novel therapeutic contribution to tissue regeneration for lung diseases. This study aimed to summarize the advancements in cell therapy involving mesenchymal stromal cells, extracellular vesicles, and immune cells such as T-cells in asthma. Our findings provide some evidence that the use of mesenchymal stem cells, their derivatives, and immune cells such as T-cells are just the initial milestone to understand how emergent cell-based therapies are effective to face the challenges to manage asthma development and progression, improving life quality.