The spatiotemporal trend of renal involvement in COVID-19: a pooled analysis of 17,134 patients.

Abstract Background The spatiotemporal trend of renal involvement in Coronavirus Disease 2019(COVID-19) patients is still unclear. Therefore, we seek to reveal the dynamics of renal involvement superimposed COVID-19 according to time and space. Methods The COVID-19 patients reporting the renal involvement were enrolled in our study. We collected the following information: the first author, patient demographics, patients enrolled period, location, definition of acute kidney injury (AKI), prevalence of AKI and renal replacement treatment (RRT). Results 17,134 patients were included finally. The overall prevalence of AKI in COVID-19 patients was 19%, which 7% of them underwent RRT. And the overall risk of AKI in patients enrolled before March 1, 2020 (9%) was significantly lower than that after March 1, 2020 (36%) (P  Conclusions This study firstly reports that renal involvement superimposed COVID-19, a comorbidity portending a poor prognosis, has become an increasingly serious problem over time, and more common outside Asia. Thus, more concerns should be offered to manage the specific group of patients.