Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA

Abstract 2-Amino-5-(thioaryl)thiazoles are potent inhibitors of TrkA (e.g., 20h , TrkA IC 50  = 0.6 nM) that show anti-proliferative effect in cellular assays. A proposed inhibitor binding mode to TrkA active site is consistent with key SAR observations.