Literature Analysis of 646 Cases of Drug-induced Cardiovascular Diseases

OBJECTIVE:To find out the incidence and general patterns of drug-induced cardiovascular diseases and to guide rational use of drugs.METHODS: By using literature metrological method.646 cases of drug-induced cardiovascular diseases which were reported in Chinese literatures in 1995 - 2000 were analysed .RESULTS: Among those 646 cases, the incidence of arrhythmia was 59.8% .The kinds of induced drugs were up to 155 and the most easily inducing one was cardiovascular system drug, which amounted to 37.2% (240/646) .Propafenone had the highest incidence of all in inducing cardiovascular diseases(75 cases) .There were 35(5.4%) fatal cases mainly caused by cardiovascular system drugs.Most of the patients with drug-induced cardiovascular diseases were in middle-age and old age.CONCLUSION: To reduce the rate of drug-induced diseases, cardiovascular system drugs should be rationally administrated and stictly supervised.