Efecto del extracto acuoso de Aloe vera (L) N L Burm sobre indicadores lipídicos de suero de conejo

Introduccion: trabajos realizados con extracto acuoso y gel hojas de Aloe vera (L) N L Burm, administrados a ratones en un modelo de hiperlipidemia aguda inducida con triton, demostraron un efecto protector al incremento de los lipidos. Objetivos: estudiar el efecto de la administracion a dosis repetida de extracto acuoso de A. vera sobre los indicadores lipidicos de suero de conejo. Metodos: conejos machos Nueva Zelandia fueron tratados con extractos acuosos de A. vera a las dosis de 17 y 34 mg/kg de peso corporal, sobre la base de solidos totales durante 6 semanas, tambien se incluyo un grupo control sin tratamiento, el peso corporal, colesterol total, HDL-colesterol, LDL colesterol y trigliceridos fueron determinados al inicio y al final del periodo del experimento. Resultados: se encontro una disminucion significativa del colesterol, LDL colesterol y trigliceridos en suero de los animales tratados con la dosis de 34 mg/kg de extracto acuoso al final del experimento, pero el HDL-colesterol no mostro variaciones. Conclusiones: la administracion de extracto acuoso de A. vera a conejo durante 6 semanas causo una disminucion significativa de los lipidos en suero. Introduction: the research works conducted with water extract and gel from Aloe vera (L.) N. L. Burm., administered to mice in a triton-induced acute hyperlipidemia pattern, showed a protective effect against the increase of lipids. Objectives: to study the effect of administration of water extract from A. vera at repeated doses on the lipid indicators of rabbit serum. Methods: male New Zealand rabbits were treated with water extracts from Aloe vera at doses of 17 and 34 mg/kg of bodyweight, on the basis of whole solids for 6 weeks. An untreated control group was included. Body weight, total cholesterol, HDL-cholesterol, LDL cholesterol and triglycerides were determined at the beginning and at the end of the experimental period. Results: it was found that cholesterol, LDL cholesterol and triglycerides significantly decreased in serum of animals treated with 34 mg/kg dose of the water extract at the end of the experiment, however, the HDL-cholesterol did not show any variation. Conclusions: the administration of water extract from Aloe vera to a rabbit for 6 weeks significantly reduced serum lipids.