Investigation of Low-Dose Fractionated Radiation Therapy as a Chemopotentiator in Advanced/Metastatic Gastrointestinal Carcinoma

by more than three thousand-fold after LOFU treatment. HSPA6 and HSPA7 had slight expression in the untreated groups but had robust upregulation after LOFU irrespective of cell types. Conclusions: Our study provides evidence that ultrasound induced an acute cellular stress response with up-regulation of protein folding genes in PCa cells. We also identified two ubiquitously up-regulated and tightly regulated heat shock proteins after LOFU. Our study demonstrated LOFU robustly induces expression of HSPA6 and HSPA7. The promoters of HSPA6 and HSPA7 have important implications for cancer gene therapy as targeted switches. Future analysis will explore the potential use of LOFU as an externally delivered controlled activation. Author Disclosure: J. Tang: None. Y. Liu: None. Z. He: None. H. Zhang: None. H. Gao: None. D.J. Leong: None. R.J. Majeska: None. C. Guha: None. H.B. Sun: None.