Correlation of dual-source computed tomography/dual-energy imaging with pathological grading of lung adenocarcinoma and its clinical value

Objective: To explore the correlation of dual-source computed tomography (DSCT)/dual-energy imaging with pathological grading of lung adenocarcinoma. Methods: A total of 47 patients with lung adenocarcinoma were selected. Tissues were histopathologically confirmed by routine DSCT scanning and dual-energy enhanced scanning. Arterial-phase and venous-phase iodine distribution images and single-energy images at 40-190 keV were obtained. The region of interest was outlined to obtain CT values. The iodine concentrations of each tumor in two phases were recorded to calculate normalized iodine concentrations (NICs). Results: The maximum diameter and minimum diameter of tumors in low differentiation (LD) group were significantly higher than those of high differentiation (HD) group (P 0.05). Conclusion: HD and LD groups could be predictably distinguished by single-energy images at low energy levels (40-70 keV) in the venous phase. Quantitative analysis of NIC in the venous phase is also valuable for predicting the pathological grade of lung adenocarcinoma.