[Evaluation of first phase insulin secretion by a nateglinide-intravenous glucose insulin release test in newly diagnosed type 2 diabetics].

Objective To evaluate the function of the first phase of insulin secretion of pancreatic B cells in newly diagnosed type 2 diabetics using nateglinide-intravenous glucose insulin release test(NG- 1VGIRT).Methods NG-IVGIRT and intravenous glucose insulin release test(IVGIRT)were done in 8 patients with newly diagnosed type 2 diabetes mellitus and NG-IVGIRT was done in 8 normal people.Insulin and glucose of blood were determined at-15,0,2,4,6,8 and 10 min in NG-IVGIRT or IVGIRT.Results The response of 0-10 min insulin to NG-IVGIRT was significantly higher than that to IVGIRT in the diabetics.The response of insulin to NG-IVGIRT in the normal controls was much higher than that in the diabetics.The area under curve(AUC)of insulin to NG-IVGIRT was apparently elevated and the AUC of glucose to NG-IVGIRT reduced in the normal controls as compared with those in the diabetics.Conclusion The results indicated that the reserve of first phase insulin secretion in newly diagnosed type 2 diabetics could be provoked in some degree by NG-IVGIRT and there was a big difference in the reserve of the first phase of insulin secretion provoked by NG-IVGIRT between newly diagnosed type 2 diabetics and normal people.