Hyperprolactinemia in Girls with Idiopathic Precocious Puberty Under Prolonged Treatment with Cyproterone Acetate

1977 
Plasma prolactin response to the acute injection of sulpiride (1.5 mg/k BW im) was measured at 0800–0900 h in 4 girls with idiopathic precocious puberty before and after 6 to 11 months of continuous therapy with 50 mg daily of cyproterone acetate (CA) orally administered. Two additional girls were examined after 26 and 28 months of therapy, respectively. Mean baseline prolactin concentrations were significantly higher in untreated girls with precocious puberty as compared to that of normal controls of the same chronological age and of a comparable degree of sexual maturation (14.5 ± 1.9 SE vs. 7.4 ± 1.8 SE ng/ml and vs. 9.5 ± 1.8 ng/ml, respectively; P <.02). Treatment with CA caused a significant further increase of plasma prolactin concentration (P<.02 as compared to pre-treatment values); no correlation was observedbetween prolactin concentration and duration of treatment. No significant change in the integrated areas of prolactin response to sulpiride occurred after prolonged CA therapy. The results s...
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