The Potential Use of Maturation In Vitro of Human Oocytes in Low Responder Patients

Purpose: To assess whether maturation in vitro of humanoocytes (MIVHO) could be an alternative treatment in lowresponders to ovarian stimulation for in vitro fertilization(IVF). Methods: Prospective case=ncontrol study. Spontaneouslyovulatory women who volunteered were included in ourprogram of MIVHO at the Instituto Valenciano deInfertilidad. Rates of oocyte retrieval, in vitro maturation,fertilization, and development up to the blastocyst stage werestudied. Results: A significantly increased rate of oocyte retrievalwas found when the pickup was performed before follicularselection. No differences were found when MIVHO was usedin a low responder patient with an ovarian content of earlyantral follicles > 5 as compared to normal responders. Conclusions: MIVHO could be a successful choice in lowresponder patients with an acceptable number of early antralfollicles. Oocyte retrieval should be performed beforefollicular selection in order to obtain more oocytes.