Epigallocatechin Is Eliminated Faster From Plasma Than Epigallocatechin Gallate: Mathematical Modeling of Green Tea Catechin Metabolism in Healthy Adults

Objectives The predominant catechins [epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin (EC), epicatechin gallate (ECG)] in green tea extract (GTE) vary in bioactivity. Our objective was to develop a physiologically relevant mathematical model of catechin metabolism and assess their fractional catabolic rates relative to their structural attributes, which may influence their bioactivities.