A new classification of generalized carcinoma of the breast based on response to therapy

Classifications of generalized carcinoma of the breast were based up to now on factors of definitely proven prognostic significance. These classifications are very useful in defining prognosis, but they help only to a limited extent in selecting treatment. We are proposing a new classification of three groups for generalized carcinoma of the breast according to objective response to therapy: to (a) responders, (b) nonresponders, and (c) patients with static disease. It is pointed out that in some cases there is discrepancy between prognosis and response to therapy, as some patients with “poor prognosis” respond dramatically to treatment while others with “good prognosis” do not respond to any type of treatment and treatment is actually harmful. It is also pointed out that our classificaiton has a dynamic meaning, as a patient can switch from one group to another. The proposed classification might be of more help in deciding the therapeutic management.