Pathology of Hidradenitis Suppurativa

The histological spectrum of HS is broad. The disease appears to be predominantly follicular and apocrine glands appear to be primarily involved in only a minority of histological specimens. Although inflammation does not appear to originate within the apocrine glands, the exclusive finding of the disease within apocrine-gland-bearing skin indicates an apocrine effect. This diversity of pathological presentation may well explain the therapeutic challenge that this condition poses.