Auditory Cortical Plasticity and Reorganization in Rats With Single-Sided Deafness During Early Developmental Period:
2019
Objective:We aimed to examine the serial change of sound-specific auditory cortical activation patterns in age-matched normal hearing (NH) and young single-sided deafness (YSSD) rats to understand the critical period that influences a benefit of a binaural hearing.Method:Experiments were performed on the age-matched 64 Sprague-Dawley rats; NH group = 45 rats, and YSSD group = 19 rats. NH rats were evaluated the multi-unit neural activities from the age of post-14 days (P14ds) to P73ds by week interval. For YSSD group, left-side cochlear ablations were done at the age of P10ds, and multineural recordings were implemented at the post-deafening (PD) 2 weeks (W), PD4W, PD6W, and PD8W, with age matching. After craniotomy, tungsten wire-based 16-channel microelectrode array was inserted to the surface of the auditory cortex. Gaussian white sound stimulation was introduced to the right ear every 500 ms, and analyses were performed of the Peri-stimulus time histogram. The parameters, including peak latency, peak ...
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
32
References
1
Citations
NaN
KQI