Influence of HGV super-infected with HIV or HCV on the virus replication

Objective: To realize human immunodeficiency virus(HIV) and hepatitis C virus(HCV) super infec ted with hepatitis G virus(HGV or GBV/C) and to probe into the mechanism of these virus infection in the body. Methods: HIV and HCV load were tested by the quantitated RT PCR in the HIV or HCV infected plasma samples respectively and the HGV RNA was detected in all of the samples. Then some of the HGV positive were sequenced. Results: 123 of 317 HIV patients were positive for HGV, the positive rate was 38.8%. Among the 91 HCV patients, 19 were positive for HGV. The positive rate is 20.9% which was less than that of HIV patients. HIV load of the patients super infected with HGV was less than that of those without HGV[(1.8±0.6)×10 copies/ml vs (1.9±1.1)×10 2copies/ml];while HGV and HCV super infection did not influence the HCV RNA load significantly[(1.5±0.6)×10 4copyes/ml vs (5.4±1.8)×10 4copies/ml]. The HGV sequences from HIV or HCV patients were compared and showed no difference markedly. Conclusion: The rate of the HIV and HGV super infection is higher than that of HCV. HGV may inhibit HIV reproduction in the body while super infection.[